AsianFin — Scientists from the University of Zurich, ETH Zurich, and Ghent University in Belgium have developed a new gene-editing method that combines advanced "genetic scissors" technology with artificial intelligence (AI) to significantly improve the precision of DNA editing.
This breakthrough provides a powerful new tool for more accurately simulating human disease mechanisms and lays the groundwork for the development of future precision gene therapies.
The research team created an AI tool called Pythia, which allows scientists to predict with unprecedented accuracy how cells will repair their DNA after being cut by gene-editing technologies like CRISPR/Cas9. Leveraging this predictive capability, the team then designed tiny DNA repair templates that act like "molecular glue." These templates guide the cell to complete gene modifications or insertions with a high degree of precision.
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